IMAX® GOLD (Ivermectin & Praziquantel) Liquid has been formulated for administration by oral drench or stomach tube (nasogastric intubation). One low- volume dose is effective against important internal parasites, including tapeworms and the arterial stages of Strongylus vulgaris, and bots. Ivermectin is derived from the avermectins, a family of potent, broad-spectrum antiparasitic agents, which are isolated from fermentation of Streptomyces avermitilis. Praziquantel is indicated for the treatment of tapeworms (Anoplocephala perfoliata, Anoplocephala magna, Paranoplecephala mammillana (adults, immature, heads and segments).
MODE OF ACTION:
IMAX® GOLD is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels; the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.
INDICATIONS:
IMAX® GOLD, when used at the recommended dose level of 200 ?g ivermectin per kilogram live weight and 1.5mg praziquantel per kilogram live weight controls the following parasites of horses:
Tapeworms: Anoplocephala perfoliata, Anoplocephala magna, Paranoplocephala mammillana (adults, immature, heads and segments).
Large Strongyles: Strongylus vulgaris (adult and arterial larval stages), Strongylus edentatus (adults and tissue stages), Strongylus equinus (adults) and Tridontophorus spp. (adults) and Craterostomum acuticaudatum (adults).
Small Strongyles: Including benzimidazole resistant strains of adult and immature: Cyathostomum spp. (adults) and Cylicocyclus spp., Cylicostephanus spp. Cylicodontophorus spp., Gyalocephalus spp., Coronocyclus spp., Parapoteriostomum spp., Petrovinema spp. and Poteriostomum spp
Pinworms: Oxyuris equi (adult and immature).
Ascarids: Parascaris equorum (adult and immature).
Hairworms: Trichostrongylus axei (adult).
Large Mouth Stomach Worms: Habronema muscae (adult).
Neck Threadworms: Onchocerca spp. (microfilariae).
Bots: Gasterophilus spp. (oral and gastric stages).
Lungworms: Dictyocaulus arnfieldi (adult and immature).
Intestinal Threadworms: Strongyloides westeri (adult).
IMAX® GOLD Liquid is also effective for control of skin lesions caused by Habronema and Draschia spp., cutaneous larvae (summer sores), and Onchocerca spp. microfilariae (cutaneous onchocerciasis).
