Manufacturer: Novartis Animal Health Australasia Pty Limited Registered Name Milbemax Tablets for Small Dogs and Puppies; Milbemax Tablets for Dogs Composition Milbemax Tablets for Small Dogs and Puppies. Milbemycin oxime 2.5 mg, praziquantel 25 mg. Milbemax Tablets for Dogs. Milbemycin oxime 12.5 mg, praziquantel 125 mg. Actions Milbemycin oxime is believed to interfere with the transmission of nerve messages in roundworms, hookworms and heartworm by binding to receptor sites on the glutamate gated chloride channels of the cell membrane, leading to hyperpolarisation and elimination of nerve signal transmission. Praziquantel causes influx of calcium at receptors on the body surface of tapeworms. This leads to membrane depolarisation and almost instantaneous contraction of the musculature (tetany), rapid vacuolisation of the syncytial tegument, and subsequent tegumental disintegration (blebbing), resulting in easier expulsion from the gastrointestinal tract or death of the tapeworm. Indications Treatment and control of roundworm (Toxocara canis, Toxascaris leonina); treatment and control of whipworm (Trichuris vulpis); treatment and control of hookworm (Ancylostoma caninum, Ancylostoma braziliense); treatment and control of tapeworm infections (Dipylidium caninum, Taenia sp. and Echinococcus granulosus); and prevention of heartworm (Dirofilaria immitis) in dogs and puppies over 2 weeks of age. Precautions Before starting Milbemax, a veterinarian should confirm that the dog is heartworm free. First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126. If in eyes, hold eyes open, flood with water for at least 15 minutes and see a doctor. Disposal Dispose of empty containers by wrapping in paper and putting in garbage. Dosage and Administration Milbemax tablets should be given by mouth. The minimum dose is milbemycin oxime 0.5 mg/kg bodyweight, and praziquantel 5 mg/kg bodyweight. Small dogs 0.5 to 5 kg. Use oblong white tablets. 0.5 to 1 kg: ½ tablet. 1 to 5 kg: 1 tablet. Dogs 5 to 50 kg. Use round white tablets. 5 to 25 kg: 1 tablet. 25 to 50 kg: 2 tablets. Dogs > 50 kg. Give a combination of tablets according to dog's weight, consistent with the recommended minimum dose. Control of gastrointestinal worms. Milbemax Tablets for Dogs should only be given to dogs over 5 kg. For puppies use Milbemax Tablets for Small Dogs. Treat puppies at 2, 4, 8 and 12 weeks of age, then every three months. Lactating bitches should be treated at the same time as their puppies. Adult dogs should be treated every three months. Heartworm prevention. Milbemax Tablets must be administered every month, preferably on the same date each month. If the interval between tablets is longer than a month by less than seven days, Milbemax Tablets should be administered immediately and the monthly dosing schedule resumed. If the interval between tablets is longer than a month by more than than seven days, a veterinarian should be consulted before recommencing Milbemax Tablets dosing schedule.
